PUBLICATION

Distinct expression patterns of syndecans in the embryonic zebrafish brain

Authors
Hofmeister, W., Devine, C.A., and Key, B.
ID
ZDB-PUB-130309-19
Date
2013
Source
Gene expression patterns : GEP   13(3-4): 126-32 (Journal)
Registered Authors
Key, Brian
Keywords
heparan sulfate proteoglycans, syndecans, axon guidance
MeSH Terms
  • Animals
  • Axons/metabolism
  • Brain/growth & development
  • Brain/metabolism*
  • Embryonic Development/genetics
  • Gene Expression Regulation, Developmental
  • Neurogenesis/genetics
  • Phylogeny
  • Signal Transduction/genetics
  • Syndecan-2/genetics*
  • Syndecan-3/genetics*
  • Syndecan-4/genetics*
  • Zebrafish/genetics*
  • Zebrafish/growth & development
  • Zebrafish Proteins/genetics*
PubMed
23434743 Full text @ Gene Expr. Patterns
Abstract

Axon pathfinding in the neuroepithelium of embryonic brain is dependent on a variety of short and long range guidance cues. Heparan sulfate proteoglycans such as syndecans act as modulators of these cues and their importance in neural development is highlighted by their phylogenetic conservation. In Drosophilia, a single syndecan is present on the surface of axon growth cones and is required for chemorepulsive signalling during midline crossing. Understanding the role of syndecans in the vertebrate nervous system is challenging given that there are four homologous genes, syndecans 1–4. We show here that syndecans 2–4 are expressed in the zebrafish embryonic brain during the major period of axon growth. These genes show differing expression patterns in the brain which provides putative insights into their functional specificity.

Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes