PUBLICATION
Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model
- Authors
- Chen, Y.H., Wang, W.H., Wang, Y.H., Lin, Z.Y., Wen, C.C., and Chern, C.Y.
- ID
- ZDB-PUB-130221-17
- Date
- 2013
- Source
- Molecules 18(2): 2052-2060 (Journal)
- Registered Authors
- Chen, Yau-Hung
- Keywords
- none
- MeSH Terms
-
- Animals
- Peroxidase/metabolism
- Wound Healing/drug effects
- Zebrafish/metabolism*
- Neutrophil Infiltration/drug effects
- Chalcone/analogs & derivatives*
- Chalcone/chemical synthesis
- Chalcone/chemistry
- Chalcone/pharmacology*
- Models, Animal
- Animal Fins/surgery
- Anti-Inflammatory Agents/chemical synthesis
- Anti-Inflammatory Agents/chemistry
- Anti-Inflammatory Agents/pharmacology*
- Larva/drug effects
- Larva/enzymology
- PubMed
- 23385341 Full text @ Molecules
Citation
Chen, Y.H., Wang, W.H., Wang, Y.H., Lin, Z.Y., Wen, C.C., and Chern, C.Y. (2013) Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a zebrafish model. Molecules. 18(2):2052-2060.
Abstract
The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line “Tg(mpx:gfp)” to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping