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ZFIN ID: ZDB-PUB-121116-5
Leukocyte migration from a fish eye's view
Deng, Q., and Huttenlocher, A.
Date: 2012
Source: Journal of Cell Science   125(17): 3949-3956 (Review)
Registered Authors: Huttenlocher, Anna
Keywords: chemotaxis, migration, neutrophil, zebrafish
MeSH Terms:
  • Animals
  • Cell Movement*
  • Cell Polarity
  • Cellular Microenvironment
  • Disease Models, Animal
  • Leukocytes/cytology*
  • Zebrafish/embryology
  • Zebrafish/metabolism*
PubMed: 23104739 Full text @ J. Cell Sci.

In the last five years, the zebrafish (Danio rerio) has rapidly gained popularity as a model system for studying leukocyte migration and trafficking in vivo. The optical clarity of zebrafish embryos, as well as the potential for genetic manipulation and the development of tools for live imaging, have provided new insight into how leukocytes migrate in response to directional cues in live animals. This Commentary discusses recent progress in our understanding of how leukocytes migrate in vivo, including the role of intracellular signaling through phosphatidylinositol 3-kinase (PI3K) in both random and directed migration. The importance of leukocyte reverse migration in the resolution of inflammation will also be discussed. Finally, we will highlight how zebrafish models have helped to provide new insight into leukocyte migration and the way in which migration is altered in disease.