Deng, Q., and Huttenlocher, A. (2012) Leukocyte migration from a fish eye's view. Journal of Cell Science. 125(17):3949-3956.
In the last five years, the zebrafish (Danio rerio) has rapidly gained popularity as a model system for studying leukocyte migration and trafficking in vivo. The optical clarity
of zebrafish embryos, as well as the potential for genetic manipulation and the development of tools for live imaging, have
provided new insight into how leukocytes migrate in response to directional cues in live animals. This Commentary discusses
recent progress in our understanding of how leukocytes migrate in vivo, including the role of intracellular signaling through
phosphatidylinositol 3-kinase (PI3K) in both random and directed migration. The importance of leukocyte reverse migration
in the resolution of inflammation will also be discussed. Finally, we will highlight how zebrafish models have helped to provide
new insight into leukocyte migration and the way in which migration is altered in disease.
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