PUBLICATION

Wnt signaling regulates postembryonic hypothalamic progenitor differentiation

Authors
Wang, X., Kopinke, D., Lin, J., McPherson, A.D., Duncan, R.N., Otsuna, H., Moro, E., Hoshijima, K., Grunwald, D.J., Argenton, F., Chien, C.B., Murtaugh, L.C., and Dorsky, R.I.
ID
ZDB-PUB-120928-3
Date
2012
Source
Developmental Cell   23(3): 624-636 (Journal)
Registered Authors
Argenton, Francesco, Chien, Chi-Bin, Dorsky, Richard, Duncan, Robert, Grunwald, David, Hoshijima, Kazuyuki, Lin, Junji, McPherson, Adam D., Moro, Enrico, Otsuna, Hideo, Wang, Xu
Keywords
none
MeSH Terms
  • Animals
  • Hypothalamus/cytology*
  • Hypothalamus/metabolism
  • Mice
  • Neurogenesis*
  • Neuroglia/cytology
  • Neuroglia/metabolism
  • Stem Cells/cytology*
  • Stem Cells/metabolism
  • Wnt Proteins/metabolism*
  • Wnt Signaling Pathway*
  • Zebrafish/embryology
  • Zebrafish/growth & development*
PubMed
22975330 Full text @ Dev. Cell
Abstract

Previous studies have raised the possibility that Wnt signaling may regulate both neural progenitor maintenance and neuronal differentiation within a single population. Here we investigate the role of Wnt/β-catenin activity in the zebrafish hypothalamus and find that the pathway is first required for the proliferation of unspecified hypothalamic progenitors in the embryo. At later stages, including adulthood, sequential activation and inhibition of Wnt activity is required for the differentiation of neural progenitors and negatively regulates radial glia differentiation. The presence of Wnt activity is conserved in hypothalamic progenitors of the adult mouse, where it plays a conserved role in inhibiting the differentiation of radial glia. This study establishes the vertebrate hypothalamus as a model for Wnt-regulated postembryonic neural progenitor differentiation and defines specific roles for Wnt signaling in neurogenesis.

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