ZFIN ID: ZDB-PUB-120830-15
Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism
Mu, Y., Li, X.Q., Zhang, B., and Du, J.L.
Date: 2012
Source: Neuron   75(4): 688-699 (Journal)
Registered Authors: Du, Jiu Lin, Mu, Yu, Zhang, Bo
Keywords: none
MeSH Terms:
  • 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
  • Acoustic Stimulation/adverse effects
  • Action Potentials/drug effects
  • Action Potentials/physiology
  • Animals
  • Apomorphine/pharmacology
  • Behavior, Animal
  • Benzazepines/pharmacology
  • Biotin/analogs & derivatives
  • Biotin/metabolism
  • Cell Communication/drug effects
  • Cell Communication/physiology*
  • Dopamine Agonists/pharmacology
  • Dopamine Antagonists/pharmacology
  • Dopaminergic Neurons/drug effects
  • Dopaminergic Neurons/physiology*
  • Escape Reaction/drug effects
  • Escape Reaction/physiology*
  • Excitatory Amino Acid Agonists/pharmacology
  • Excitatory Postsynaptic Potentials/drug effects
  • Flufenamic Acid/pharmacology
  • Functional Laterality
  • Glycyrrhetinic Acid/pharmacology
  • Hypothalamus/cytology*
  • In Vitro Techniques
  • Larva
  • Light
  • Locomotion/physiology*
  • Microscopy, Confocal
  • Morpholinos/pharmacology
  • Patch-Clamp Techniques
  • Photic Stimulation/methods
  • Psychoacoustics
  • Receptors, Dopamine D1/physiology
  • Signal-To-Noise Ratio
  • Time Factors
  • Valine/analogs & derivatives
  • Valine/pharmacology
  • Visual Pathways/drug effects
  • Visual Pathways/physiology*
  • Zebrafish
PubMed: 22920259 Full text @ Neuron

Visual cues often modulate auditory signal processing, leading to improved sound detection. However, the synaptic and circuit mechanism underlying this cross-modal modulation remains poorly understood. Using larval zebrafish, we first established a cross-modal behavioral paradigm in which a preceding flash enhances sound-evoked escape behavior, which is known to be executed through auditory afferents (VIIIth nerves) and command-like neurons (Mauthner cells). In vivo recording revealed that the visual enhancement of auditory escape is achieved by increasing sound-evoked Mauthner cell responses. This increase in Mauthner cell responses is accounted for by the increase in the signal-to-noise ratio of sound-evoked VIIIth nerve spiking and efficacy of VIIIth nerve-Mauthner cell synapses. Furthermore, the visual enhancement of Mauthner cell response and escape behavior requires light-responsive dopaminergic neurons in the caudal hypothalamus and D1 dopamine receptor activation. Our findings illustrate a cooperative neural mechanism for visual modulation of audiomotor processing that involves dopaminergic neuromodulation.