PUBLICATION
On the Biological Properties of Alkynyl Phosphine Gold(I) Complexes
- Authors
- Meyer, A., Bagowski, C.P., Kokoschka, M., Stefanopoulou, M., Alborzinia, H., Can, S., Vlecken, D.H., Sheldrick, W.S., Wölfl, S., and Ott, I.
- ID
- ZDB-PUB-120807-15
- Date
- 2012
- Source
- Angewandte Chemie (International ed. in English) 51(35): 8895-8899 (Journal)
- Registered Authors
- Bagowski, Christoph P.
- Keywords
- angiogenesis, bioorganometallic chemistry, cellular uptake, gold complexes, thioredoxin reductase
- MeSH Terms
-
- Animals
- Cell Proliferation/drug effects
- Coordination Complexes/chemistry*
- Coordination Complexes/pharmacology
- Coordination Complexes/toxicity
- Embryo, Nonmammalian/physiology
- Gold/chemistry*
- HT29 Cells
- Humans
- MCF-7 Cells
- Neovascularization, Physiologic/drug effects
- Phosphines/chemistry*
- Thioredoxin-Disulfide Reductase/antagonists & inhibitors
- Thioredoxin-Disulfide Reductase/metabolism
- Zebrafish/growth & development
- PubMed
- 22848030 Full text @ Angew. Chem. Int. Ed. Engl.
Citation
Meyer, A., Bagowski, C.P., Kokoschka, M., Stefanopoulou, M., Alborzinia, H., Can, S., Vlecken, D.H., Sheldrick, W.S., Wölfl, S., and Ott, I. (2012) On the Biological Properties of Alkynyl Phosphine Gold(I) Complexes. Angewandte Chemie (International ed. in English). 51(35):8895-8899.
Abstract
Golden times for metal-based drugs? Alkynyl triphenylphosphine gold(I) complexes display interesting biological properties and show high potential for future drug development. They are strong inhibitors of the enzyme thioredoxin reductase, trigger antiproliferative effects in tumor cells, and influence tumor cell metabolism, mitochondrial respiration, and angiogenesis in zebrafish embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping