PUBLICATION
Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo
- Authors
- Yan, H., Teh, C., Sreejith, S., Zhu, L., Kwok, A., Fang, W., Ma, X., Nguyen, K.T., Korzh, V., and Zhao, Y.
- ID
- ZDB-PUB-120718-13
- Date
- 2012
- Source
- Angewandte Chemie (International ed. in English) 51(33): 8373-8377 (Journal)
- Registered Authors
- Korzh, Vladimir, Teh, Cathleen
- Keywords
- drug delivery, mesoporous silica nanoparticles, nanoparticles, photothermal switches, zebrafish
- MeSH Terms
-
- Photochemical Processes
- Silicon Dioxide/administration & dosage*
- Silicon Dioxide/chemistry
- Surface Properties
- Zebrafish
- Animals
- Rotaxanes/chemistry
- Porosity
- Larva
- Nanoparticles/administration & dosage*
- Nanoparticles/chemistry
- Curcumin/chemistry
- Drug Delivery Systems*
- Temperature*
- PubMed
- 22777795 Full text @ Angew. Chem. Int. Ed. Engl.
Citation
Yan, H., Teh, C., Sreejith, S., Zhu, L., Kwok, A., Fang, W., Ma, X., Nguyen, K.T., Korzh, V., and Zhao, Y. (2012) Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo. Angewandte Chemie (International ed. in English). 51(33):8373-8377.
Abstract
A new class of photothermal-responsive [2]rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon trans?cis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping