PUBLICATION
Hooked! Modeling human disease in zebrafish
- Authors
- Santoriello, C., and Zon, L.I.
- ID
- ZDB-PUB-120706-12
- Date
- 2012
- Source
- J. Clin. Invest. 122(7): 2337-2343 (Review)
- Registered Authors
- Santoriello, Cristina, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Male
- Zebrafish/anatomy & histology
- Zebrafish/genetics*
- Zebrafish/physiology
- Animals
- Heart Diseases/genetics
- Heart Diseases/pathology
- Muscular Dystrophy, Duchenne/drug therapy
- Muscular Dystrophy, Duchenne/genetics
- Drug Screening Assays, Antitumor*
- Disease Models, Animal*
- Female
- Neoplasms/drug therapy
- Neoplasms/genetics
- Eye Diseases/genetics
- Kidney Diseases/genetics
- Kidney Diseases/pathology
- Central Nervous System Diseases/drug therapy
- Central Nervous System Diseases/genetics
- Humans
- Hematologic Diseases/genetics
- Genetic Engineering
- PubMed
- 22751109 Full text @ J. Clin. Invest.
Citation
Santoriello, C., and Zon, L.I. (2012) Hooked! Modeling human disease in zebrafish. J. Clin. Invest.. 122(7):2337-2343.
Abstract
Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of zebrafish organs are strikingly similar to those of humans, and the ease of creating mutant or transgenic fish has facilitated the generation of disease models. Here, we highlight the use of zebrafish for defining disease pathways and for discovering new therapies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping