Toxicological effect of joint cadmium selenium quantum dots and copper ion exposure on zebrafish
- Authors
- Zhang, W., Sun, X., Chen, L., Lin, K.F., Dong, Q.X., Huang, C.J., Fu, R.B., and Zhu, J.
- ID
- ZDB-PUB-120702-30
- Date
- 2012
- Source
- Environmental toxicology and chemistry 31(9): 2117-2123 (Journal)
- Registered Authors
- Zhang, Wei
- Keywords
- CdSe, quantum dots, copper, zebrafish, facilitated transport, toxicological effect
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Apoptosis
- Biological Transport
- Body Burden
- Cadmium/metabolism
- Cadmium/toxicity*
- Cations, Divalent
- Copper/metabolism
- Copper/toxicity*
- Embryo, Nonmammalian/abnormalities
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/drug effects
- Embryonic Development
- Environmental Pollutants/metabolism
- Environmental Pollutants/toxicity*
- Larva/cytology
- Larva/drug effects
- Larva/metabolism
- Metal Nanoparticles/toxicity*
- Proto-Oncogene Protein c-fli-1/genetics
- Quantum Dots*
- Selenium/metabolism
- Selenium/toxicity*
- Zebrafish/abnormalities
- Zebrafish/embryology*
- Zebrafish/growth & development*
- Zebrafish/metabolism
- PubMed
- 22714141 Full text @ Environ. Toxicol. Chem.
Quantum dots (QDs) have strong adsorption capacity; therefore, their potential toxicity to aquatic organisms from the facilitated transport of other trace toxic pollutants when they coexist,has received increasing interest. However, the impact of cadmium selenium (CdSe) QDs and copper ion (Cu2+) joint exposure on zebrafish embryo and larvae remains almost unknown. Therefore, the present study was performed to determine the developmental toxicities to zebrafish exposed to combined pollution with CdSe QDs (500 μg/L) and Cu2+ (0, 0.1, 1, 10, and 100μg/L CuC12) compared with single exposure. Our findings for the first time revealed that: (1) QDs facilitated the accumulation of Cu2+ in zebrafish; (2) QDs caused higher mortality, lower hatch rate, and more malformations of the exposed zebrafish; (3) junction, bifurcation, crossing, particles, and aggregation of the exposed FLI-1 transgenic zebrafish larvae can be observed; (4) embryo cell apoptosis appeared in the head and tail region; and (5) synergistic effects played an important role during joint exposure. These observations provide a basic understanding of CdSe QDs and Cu2+ joint toxicity to aquatic organisms and suggest the need for additional research to identify the toxicological mechanism.