PUBLICATION

MicroRNAs in inner ear biology and pathogenesis

Authors
Patel, M., and Hu, B.H.
ID
ZDB-PUB-120410-11
Date
2012
Source
Hearing Research   287(1-2): 6-14 (Review)
Registered Authors
Hu, Bo
Keywords
none
MeSH Terms
  • Animals
  • Ear, Inner/metabolism*
  • Ear, Inner/pathology
  • Ear, Inner/physiopathology
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • Hair Cells, Auditory/metabolism
  • Hair Cells, Auditory/pathology
  • Hearing/genetics*
  • Hearing Loss/genetics*
  • Hearing Loss/pathology
  • Hearing Loss/physiopathology
  • Humans
  • MicroRNAs/metabolism*
  • Phenotype
  • Regeneration
PubMed
22484222 Full text @ Hear. Res.
Abstract

MicroRNAs (miRNA) are a group of small noncoding RNAs that regulate gene expression. The discovery of these small RNAs has added a new layer of complexity to molecular biology. Every day, new advances are being made in understanding the biochemistry and genetics of miRNAs and their roles in cellular function and homeostasis. Studies indicate diverse roles for miRNAs in inner ear biology and pathogenesis. This article reviews recent developments in miRNA research in the field of inner ear biology. A brief history of miRNA discovery is discussed, and their genomics and functional roles are described. Advances in the understanding of miRNA involvement in inner ear development in the zebrafish and the mouse are presented. Finally, this review highlights the potential roles of miRNAs in genetic hearing loss, hair cell regeneration, and inner ear pathogenesis resulting from various pathological insults.

Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping