PUBLICATION
Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo
- Authors
- Zhou, Y., Li, J.Y., Chu, K.H., Liu, K., Yao, C., and Li, J.Y.
- ID
- ZDB-PUB-120306-25
- Date
- 2012
- Source
- Chemical communications (Cambridge, England) 48(39): 4677-4679 (Journal)
- Registered Authors
- Zhou, Yi
- Keywords
- none
- MeSH Terms
-
- Brain Chemistry
- Fluoresceins/chemistry*
- Fluorescent Dyes/chemistry*
- Animals
- Intestines/chemistry
- Zebrafish/embryology
- Hypochlorous Acid/analysis*
- Hypochlorous Acid/chemistry
- Solubility
- Mice
- Water/chemistry
- Oxidation-Reduction
- Ether/chemistry*
- NIH 3T3 Cells
- PubMed
- 22389025 Full text @ Chem. Commun. (Camb.)
Citation
Zhou, Y., Li, J.Y., Chu, K.H., Liu, K., Yao, C., and Li, J.Y. (2012) Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo. Chemical communications (Cambridge, England). 48(39):4677-4679.
Abstract
We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on the basis of a specific HOCl-promoted oxidation reaction. This work also provided a useful method to monitor the accumulated HOCl in specific organelles using a zebrafish model.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping