Encoding of luminance and contrast by linear and nonlinear synapses in the retina
- Authors
- Odermatt, B., Nikolaev, A., and Lagnado, L.
- ID
- ZDB-PUB-120301-11
- Date
- 2012
- Source
- Neuron 73(4): 758-773 (Journal)
- Registered Authors
- Lagnado, Leon, Odermatt, Benjamin
- Keywords
- none
- MeSH Terms
-
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism
- Embryo, Nonmammalian
- Contrast Sensitivity/physiology*
- Gene Expression Regulation, Developmental
- Photic Stimulation
- Models, Neurological*
- Synaptic Transmission/genetics
- Synaptic Transmission/physiology*
- Luminescence*
- Green Fluorescent Proteins/genetics
- Green Fluorescent Proteins/metabolism
- Pineal Gland/metabolism
- Light
- Nonlinear Dynamics
- Carrier Proteins/genetics
- Carrier Proteins/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism
- Zebrafish
- Calcium Signaling/genetics
- Calcium Signaling/physiology
- Synapses/physiology*
- Animals
- Retina/cytology*
- Sensory Receptor Cells/physiology*
- Animals, Genetically Modified
- PubMed
- 22365549 Full text @ Neuron
Understanding how neural circuits transmit information is technically challenging because the neural code is contained in the activity of large numbers of neurons and synapses. Here, we use genetically encoded reporters to image synaptic transmission across a population of sensory neurons—bipolar cells in the retina of live zebrafish. We demonstrate that the luminance sensitivities of these synapses varies over 104 with a log-normal distribution. About half the synapses made by ON and OFF cells alter their polarity of transmission as a function of luminance to generate a triphasic tuning curve with distinct maxima and minima. These nonlinear synapses signal temporal contrast with greater sensitivity than linear ones. Triphasic tuning curves increase the dynamic range over which bipolar cells signal light and improve the efficiency with which luminance information is transmitted. The most efficient synapses signaled luminance using just 1 synaptic vesicle per second per distinguishable gray level.