Neuronal expression of class 6 semaphorins in zebrafish
- Authors
- Ebert, A.M., Lamont, R.E., Childs, S.J., and McFarlane, S.
- ID
- ZDB-PUB-120215-24
- Date
- 2012
- Source
- Gene expression patterns : GEP 12(3-4): 117-122 (Journal)
- Registered Authors
- Childs, Sarah J., Lamont, Ryan
- Keywords
- zebrafish, semaphorin, gene expression, development, in situ hybridization, neuronal
- MeSH Terms
-
- Animals
- Axons/metabolism*
- Gene Expression Regulation, Developmental*
- Mesencephalon/cytology
- Mesencephalon/metabolism
- Phylogeny
- Retinal Ganglion Cells/metabolism
- Semaphorins/genetics*
- Semaphorins/metabolism
- Superior Colliculi/cytology
- Superior Colliculi/metabolism
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 22330030 Full text @ Gene Expr. Patterns
Semaphorins are a large family of guidance molecules identified by an extracellular SEMA domain. Classes 1 and 2 are derived from invertebrates, classes 3–7 are vertebrate and class 8 (v) are viral semaphorins. Class 6 semaphorins are reported to have a wide variety of roles including in axon guidance, transcriptional regulation and cancer. Here we report the identification and expression of four class 6 semaphorins (6A, 6Ba, 6Bb and 6Dl) in three stages of larval development in zebrafish (24, 48 and 72 hours postfertilization). Our data indicate that each of the class 6 semaphorins shows a distinct pattern of expression in the developing nervous system that is dynamic over the first 3 days of embryonic development. These data suggest that the individual class 6 semaphorins have diverse roles in nervous system development.