ZFIN ID: ZDB-PUB-111111-1
Systematic Approaches to Toxicology in the Zebrafish
Peterson, R.T., and MacRae, C.A.
Date: 2012
Source: Annual Review of Pharmacology and Toxicology   52: 433-53 (Review)
Registered Authors: MacRae, Calum A.
Keywords: none
MeSH Terms:
  • Animals
  • Carcinogenicity Tests
  • Drug Delivery Systems
  • Drug Design
  • Drug Discovery
  • Drug Evaluation, Preclinical/methods*
  • Gastrointestinal Tract/drug effects
  • Heart/drug effects
  • Liver/drug effects
  • Models, Animal
  • Muscles/drug effects
  • Neurons/drug effects
  • Pharmaceutical Preparations
  • Pharmacokinetics
  • Phenotype
  • Toxicity Tests*
  • Zebrafish
PubMed: 22017682 Full text @ Annu. Rev. Pharmacol. Toxicol.
As the current paradigms of drug discovery evolve, it has become clear that a more comprehensive understanding of the interactions between small molecules and organismal biology will be vital. The zebrafish is emerging as a scalable vertebrate complement to existing in vitro technologies and established preclinical in vivo models. In this review, we highlight the current status of zebrafish toxicology studies, identify potential future niches for the model in the drug development pipeline, and define the hurdles that must be overcome as zebrafish technologies are refined for systematic toxicology.