PUBLICATION
Zebrafish: model for the study of inflammation and the innate immune response to infectious diseases
- Authors
- Novoa, B., and Figueras, A.
- ID
- ZDB-PUB-111011-23
- Date
- 2012
- Source
- Advances in experimental medicine and biology 946: 253-275 (Chapter)
- Registered Authors
- Figueras, Antonio, Novoa, Beatriz
- Keywords
- zebrafish (danio rerio), inflammation, innate immunity, infectious disease, ontogeny
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Immunity, Innate/immunology*
- Infections/immunology*
- Inflammation/immunology*
- Zebrafish/immunology*
- PubMed
- 21948373 Full text @ Adv. Exp. Med. Biol.
Citation
Novoa, B., and Figueras, A. (2012) Zebrafish: model for the study of inflammation and the innate immune response to infectious diseases. Advances in experimental medicine and biology. 946:253-275.
Abstract
The zebrafish (Danio rerio) has been extensively used in biomedical research as a model to study vertebrate development and hematopoiesis and recently,
it has been adopted into varied fields including immunology. After fertilization, larvae survive with only the innate immune
responses because adaptive immune system is morphologically and functionally mature only after 4–6 weeks postfertilization.
This temporal separation provides a suitable system to study the vertebrate innate immune response in vivo, independently from the adaptive immune response. The transparency of early life stages allows a useful real-time visualization.
Adult zebrafish which have complete (innate and adaptative) immune systems offer also advantages over other vertebrate infection
models: small size, relatively rapid life cycle, ease of breeding, and a growing list of molecular tools for the study of
infectious diseases. In this review, we have tried to give some examples of the potential of zebrafish as a valuable model
in innate immunity and inflammation studies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping