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ZFIN ID: ZDB-PUB-110914-1
Diverse functions for the semaphorin receptor PlexinD1 in development and disease
Gay, C.M., Zygmunt, T., and Torres-Vazquez, J.
Date: 2011
Source: Developmental Biology   349(1): 1-19 (Review)
Registered Authors: Gay, Carl Michael, Torres-Vazquez, Jesus, Zygmunt, Tomasz
Keywords: semaphorin, sema, plexin, plxn, plexinD1, plxnD1, signaling, review, blood vessel, angiogenesis, nervous system, axon guidance, tumor, cancer, immune
MeSH Terms:
  • Animals
  • Gene Expression Regulation, Developmental
  • Humans
  • Receptors, Cell Surface/chemistry
  • Receptors, Cell Surface/genetics
  • Receptors, Cell Surface/metabolism*
  • Semaphorins/metabolism*
  • Signal Transduction
PubMed: 20880496 Full text @ Dev. Biol.
Plexins are a family of single-pass transmembrane proteins that serve as cell surface receptors for Semaphorins during the embryonic development of animals. Semaphorin-Plexin signaling is critical for many cellular aspects of organogenesis, including cell migration, proliferation and survival. Until recently, little was known about the function of PlexinD1, the sole member of the vertebrate-specific PlexinD (PlxnD1) subfamily. Here we review novel findings about PlxnD1's roles in the development of the cardiovascular, nervous and immune systems and salivary gland branching morphogenesis and discuss new insights concerning the molecular mechanisms of PlxnD1 activity.