PUBLICATION

Modeling anxiety using adult zebrafish: A conceptual review

Authors
Stewart, A., Gaikwad, S., Kyzar, E., Green, J., Roth, A., and Kalueff, A.V.
ID
ZDB-PUB-110817-1
Date
2012
Source
Neuropharmacology   62(1): 135-43 (Review)
Registered Authors
Kalueff, Allan V.
Keywords
zebrafish, anxiety, novelty-based paradigms, pharmacological and genetic manipulations, bioinformatics, omics-based tools
MeSH Terms
  • Animals
  • Anxiety/pathology*
  • Anxiety/physiopathology*
  • Avoidance Learning
  • Dark Adaptation
  • Disease Models, Animal
  • Exploratory Behavior
  • Humans
  • Social Behavior
  • Zebrafish
PubMed
21843537 Full text @ Neuropharmacology
Abstract
Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral research. Mounting evidence shows the suitability of zebrafish to model various aspects of anxiety-related states. Here, we evaluate established and novel approaches to uncover the molecular substrates, genetic pathways and neural circuits of anxiety using adult zebrafish. Experimental approaches to modeling anxiety in zebrafish include novelty-based paradigms, pharmacological and genetic manipulations, as well as innovative video-tracking, 3D-reconstructions and bioinformatics-based searchable databases and omics-based tools. Complementing traditional rodent models of anxiety, we provide a conceptual framework for the wider application of zebrafish and other aquatic models in anxiety research.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping