PUBLICATION
Modeling anxiety using adult zebrafish: A conceptual review
- Authors
- Stewart, A., Gaikwad, S., Kyzar, E., Green, J., Roth, A., and Kalueff, A.V.
- ID
- ZDB-PUB-110817-1
- Date
- 2012
- Source
- Neuropharmacology 62(1): 135-43 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- zebrafish, anxiety, novelty-based paradigms, pharmacological and genetic manipulations, bioinformatics, omics-based tools
- MeSH Terms
-
- Anxiety/pathology*
- Anxiety/physiopathology*
- Disease Models, Animal
- Animals
- Avoidance Learning
- Zebrafish
- Humans
- Social Behavior
- Exploratory Behavior
- Dark Adaptation
- PubMed
- 21843537 Full text @ Neuropharmacology
Citation
Stewart, A., Gaikwad, S., Kyzar, E., Green, J., Roth, A., and Kalueff, A.V. (2012) Modeling anxiety using adult zebrafish: A conceptual review. Neuropharmacology. 62(1):135-43.
Abstract
Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral research. Mounting evidence shows the suitability of zebrafish to model various aspects of anxiety-related states. Here, we evaluate established and novel approaches to uncover the molecular substrates, genetic pathways and neural circuits of anxiety using adult zebrafish. Experimental approaches to modeling anxiety in zebrafish include novelty-based paradigms, pharmacological and genetic manipulations, as well as innovative video-tracking, 3D-reconstructions and bioinformatics-based searchable databases and omics-based tools. Complementing traditional rodent models of anxiety, we provide a conceptual framework for the wider application of zebrafish and other aquatic models in anxiety research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping