PUBLICATION
Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish
- Authors
- Lawson, N.D., and Wolfe, S.A.
- ID
- ZDB-PUB-110719-37
- Date
- 2011
- Source
- Developmental Cell 21(1): 48-64 (Review)
- Registered Authors
- Lawson, Nathan, Wolfe, Scot A.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Biology
- Developmental Biology/methods*
- Genetic Techniques*
- Models, Biological
- Zebrafish/embryology*
- Zebrafish/genetics*
- PubMed
- 21763608 Full text @ Dev. Cell
Citation
Lawson, N.D., and Wolfe, S.A. (2011) Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish. Developmental Cell. 21(1):48-64.
Abstract
The development of facile forward and reverse genetic approaches has propelled the deconvolution of gene function in biology. While the origins of these techniques reside in the study of single-cell or invertebrate organisms, in many cases these approaches have been applied to vertebrate model systems to gain powerful insights into gene function during embryonic development. This perspective provides a summary of the major forward and reverse genetic approaches that have contributed to the study of vertebrate gene function in zebrafish, which has become an established model for the study of animal development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping