PUBLICATION
Brain regionalisation: Of signalling centres and boundaries
- Authors
- Cavodeassi, F., and Houart, C.
- ID
- ZDB-PUB-110629-21
- Date
- 2012
- Source
- Developmental Neurobiology 72(3): 218-233 (Review)
- Registered Authors
- Cavodeassi, Florencia, Houart, Corinne
- Keywords
- brain, CNS, neural plate, local organisers, signalling centres, morphogens, pattern formation, fate specification
- MeSH Terms
-
- Cell Communication/physiology*
- Morphogenesis/physiology
- Signal Transduction/physiology*
- Zebrafish
- Brain/embryology
- Brain/growth & development*
- Transcription, Genetic/physiology
- Humans
- Animals
- PubMed
- 21692189 Full text @ Dev. Neurobiol.
Citation
Cavodeassi, F., and Houart, C. (2012) Brain regionalisation: Of signalling centres and boundaries. Developmental Neurobiology. 72(3):218-233.
Abstract
Our knowledge of the general mechanisms controlling the formation of the vertebrate central nervous system has advanced tremendously in the last decade. Here, we discuss the impact of the combined use of cell manipulation, in vivo imaging and genetics in the zebrafish on recent progress in understanding how signalling processes progressively control regionalisation of the central nervous system. We highlight the unresolved issues and speculate upon the fundamental role the zebrafish will continue having in answering them.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping