ZFIN ID: ZDB-PUB-110628-24
One step forward: The use of transgenic zebrafish tumor model in drug screens
Huang, X., Nguyen, A.T., Li, Z., Emelyanov, A., Parinov, S., and Gong, Z.
Date: 2011
Source: Birth defects research. Part C, Embryo today : reviews   93(2): 173-181 (Review)
Registered Authors: Gong, Zhiyuan, Li, Zhen, Parinov, Serguei
Keywords: zebrafish, drug screening, liver cancer, transgenic fish
MeSH Terms:
  • Animals
  • Animals, Genetically Modified*
  • Drug Discovery/methods*
  • Drug Screening Assays, Antitumor/methods*
  • Gene Expression Regulation, Neoplastic/genetics
  • Gene Expression Regulation, Neoplastic/physiology*
  • Liver Neoplasms/drug therapy*
  • Liver Neoplasms/genetics
  • Liver Neoplasms/physiopathology
  • Models, Animal*
  • Signal Transduction/genetics
  • Signal Transduction/physiology*
  • Zebrafish*
PubMed: 21671356 Full text @ Birth Defects Res. C Embryo Today
ABSTRACT
The zebrafish (Danio rerio) has been an experimental model in the developmental biology and toxicology since the 1950s. In recent years, with the aid of transgenic technology, it has also gained an increasing popularity to model human diseases, including various cancers. As a feasible vertebrate model for large-scale chemical screens, the zebrafish has also given us a new option for the search of potential anticancer drugs. It is hopeful that in the near future with automation and analytical tools, drug development processes will be significantly shortened for quick and effective identification of candidate drugs.
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