PUBLICATION

Evolutionary plasticity of segmentation clock networks

Authors
Krol, A.J., Roellig, D., Dequéant, M.L., Tassy, O., Glynn, E., Hattem, G., Mushegian, A., Oates, A.C., and Pourquié, O.
ID
ZDB-PUB-110613-22
Date
2011
Source
Development (Cambridge, England)   138(13): 2783-2792 (Journal)
Registered Authors
Oates, Andrew, Roellig, Daniela
Keywords
somitogenesis, segmentation, evolution, cyclic genes, segmentation clock, microarray, chicken, zebrafish, mouse, notch, wnt, FGF
MeSH Terms
  • Polymerase Chain Reaction
  • Oligonucleotide Array Sequence Analysis
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/metabolism
  • Evolution, Molecular*
  • Receptors, Notch/genetics
  • Receptors, Notch/metabolism
  • Mice
  • Animals
  • Zebrafish
  • Chickens
  • In Situ Hybridization
  • Wnt Proteins/genetics
  • Wnt Proteins/metabolism
  • Signal Transduction/genetics
  • Signal Transduction/physiology
  • Biological Clocks/genetics
  • Biological Clocks/physiology*
(all 18)
PubMed
21652651 Full text @ Development
Abstract
The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.
Genes / Markers
Figures
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Expression
Phenotype
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Mutations / Transgenics
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Human Disease / Model
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Sequence Targeting Reagents
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Fish
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Antibodies
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Orthology
No data available
Engineered Foreign Genes
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Mapping
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Citation
Krol, A.J., Roellig, D., Dequéant, M.L., Tassy, O., Glynn, E., Hattem, G., Mushegian, A., Oates, A.C., and Pourquié, O. (2011) Evolutionary plasticity of segmentation clock networks. Development (Cambridge, England). 138(13):2783-2792.