|ZFIN ID: ZDB-PUB-110609-14|
Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish
Yamauchi, H., Goto, M., Katayama, M., Miyake, A., and Itoh, N.
|Source:||Biochemical and Biophysical Research Communications 409(4): 705-10 (Journal)|
|Registered Authors:||Itoh, Nobuyuki, Miyake, Ayumi|
|Keywords:||Fgf; Fgf20b; Cranial neural crest; Pharyngeal arch; Ectomesenchyme; Zebrafish|
|PubMed:||21621510 Full text @ Biochem. Biophys. Res. Commun.|
Yamauchi, H., Goto, M., Katayama, M., Miyake, A., and Itoh, N. (2011) Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish. Biochemical and Biophysical Research Communications. 409(4):705-10.
ABSTRACTIn cranial skeletal development, the establishment of the ectomesenchymal lineage within the cranial neural crest is of great significance. Fgfs are polypeptide growth factors with diverse functions in development and metabolism. Fgf20b knockdown zebrafish embryos showed dysplastic neurocranial and pharyngeal cartilages. Ectomesenchymal cells from cranial neural crest cells were significantly decreased in Fgf20b knockdown embryos, but cranial neural crest cells with a non-ectomesnchymal fate were increased. However, the proliferation and apoptosis of cranial neural crest cells were essentially unchanged. Fgfr1 knockdown embryos also showed dysplastic neurocranial and pharyngeal cartilages. The present findings indicate that Fgf20b is required for ectomesenchymal fate establishment via the activation of Fgfr1 in zebrafish.