Zebrafish models to study drug abuse-related phenotypes
- Stewart, A., Wong, K., Cachat, J., Gaikwad, S., Kyzar, E., Wu, N., Hart, P., Piet, V., Utterback, E., Elegante, M., Tien, D., and Kalueff, A.V.
- Reviews in the Neurosciences 22(1): 95-105 (Review)
- Registered Authors
- Cachat, Jonathan, Kalueff, Allan V.
- anxiety, drug abuse, cortisol, stress tolerance, withdrawal, zebrafish
- MeSH Terms
- Disease Models, Animal*
- Substance Withdrawal Syndrome
- Substance-Related Disorders/physiopathology*
- 21615264 Full text @ Rev. Neurosci.
Stewart, A., Wong, K., Cachat, J., Gaikwad, S., Kyzar, E., Wu, N., Hart, P., Piet, V., Utterback, E., Elegante, M., Tien, D., and Kalueff, A.V. (2011) Zebrafish models to study drug abuse-related phenotypes. Reviews in the Neurosciences. 22(1):95-105.
Mounting evidence implicates the zebrafish (Danio rerio) as a promising model species for reward and addiction research. Modeling drug abuse-related behavior in both adult and larval zebrafish produced a wealth of clinically translatable data, also demonstrating their sensitivity to various drugs of abuse and the ability to develop tolerance. Several studies have also applied withdrawal paradigms to model the adverse effects of drug abuse in zebrafish. In this review, we summarize recent findings of a wide spectrum of zebrafish drug abuse-related behavioral and physiological phenotypes, discuss the existing challenges, and outline potential future directions of research in this field.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes