ZFIN ID: ZDB-PUB-110524-23
Behavioral screening for neuroactive drugs in zebrafish
Rihel, J., and Schier, A.F.
Date: 2012
Source: Developmental Neurobiology   72(3): 373-385 (Review)
Registered Authors: Rihel, Jason, Schier, Alexander
Keywords: none
MeSH Terms:
  • Animals
  • Behavior, Animal/drug effects*
  • Behavior, Animal/physiology
  • Central Nervous System Stimulants/pharmacology
  • Drug Evaluation, Preclinical/methods
  • Humans
  • Pharmaceutical Preparations/administration & dosage*
  • Sleep/drug effects
  • Sleep/physiology
  • Wakefulness/drug effects
  • Wakefulness/physiology
  • Zebrafish*/physiology
PubMed: 21567979 Full text @ Dev. Neurobiol.
The larval zebrafish has emerged as a vertebrate model system amenable to small molecule screens for probing diverse biological pathways. Two large-scale small molecule screens examined the effects of thousands of drugs on larval zebrafish sleep/wake and photomotor response behaviors. Both screens identified hundreds of molecules that altered zebrafish behavior in distinct ways. The behavioral profiles induced by these small molecules enabled the clustering of compounds according to shared phenotypes. This approach identified regulators of sleep/wake behavior and revealed the biological targets for poorly characterized compounds. Behavioral screening for neuroactive small molecules in zebrafish is an attractive complement to in vitro screening efforts, because the complex interactions in the vertebrate brain can only be revealed in vivo.