PUBLICATION
Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2
- Authors
- Verhoeven, M.C., Haase, C., Christoffels, V.M., Weidinger, G., and Bakkers, J.
- ID
- ZDB-PUB-110524-22
- Date
- 2011
- Source
- Birth defects research. Part A, Clinical and molecular teratology 91(6): 435-40 (Journal)
- Registered Authors
- Bakkers, Jeroen, Haase, Christa, Weidinger, Gilbert
- Keywords
- wnt, β-catenin, BMP4, BMP2, tbx2, atrioventricular canal (AVC), zebrafish, alk2, alk8, conduction
- MeSH Terms
-
- Wnt Signaling Pathway*
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism*
- beta Catenin/genetics
- beta Catenin/metabolism
- Mutation
- Heart Ventricles/embryology*
- Heart Ventricles/metabolism*
- Wnt Proteins/genetics
- Wnt Proteins/metabolism
- Activin Receptors, Type I
- Bone Morphogenetic Protein 4/genetics
- Bone Morphogenetic Protein 4/metabolism*
- Heart Atria/embryology
- Heart Valves/embryology
- Animals
- Cell Differentiation/genetics
- Bone Morphogenetic Protein Receptors/genetics
- Gene Expression Regulation, Developmental
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- T-Box Domain Proteins/genetics*
- PubMed
- 21567896 Full text @ Birth Defects Res. Part A Clin. Mol. Teratol.
Citation
Verhoeven, M.C., Haase, C., Christoffels, V.M., Weidinger, G., and Bakkers, J. (2011) Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2. Birth defects research. Part A, Clinical and molecular teratology. 91(6):435-40.
Abstract
In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects of its formation are the most common form of congenital heart defects. Using mutant and transgenic approaches in zebrafish, this study demonstrates that Wnt/β-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC and consequently the proper patterning of the myocardium. Furthermore, genetic analysis shows that Wnt/β-catenin signaling is upstream and in a linear pathway with BMP and Tbx2 during AVC specification. Birth Defects Research(Part A), 2011.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping