PUBLICATION
Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging
- Authors
- Lee, J.H., So, J.H., Jeon, J.H., Choi, E.B., Lee, Y.R., Chang, Y.T., Kim, C.H., Bae, M.A., and Ahn, J.H.
- ID
- ZDB-PUB-110523-13
- Date
- 2011
- Source
- Chemical communications (Cambridge, England) 47(26): 7500-2 (Journal)
- Registered Authors
- Kim, Cheol-Hee, So, Ju-Hoon
- Keywords
- none
- MeSH Terms
-
- Fluorescent Dyes/chemical synthesis*
- Fluorescent Dyes/chemistry*
- Lipid Metabolism*
- Adipose Tissue/metabolism
- Mice
- Molecular Imaging/methods*
- Zebrafish
- Animals
- 3T3-L1 Cells
- PubMed
- 21552617 Full text @ Chem. Commun. (Camb.)
Citation
Lee, J.H., So, J.H., Jeon, J.H., Choi, E.B., Lee, Y.R., Chang, Y.T., Kim, C.H., Bae, M.A., and Ahn, J.H. (2011) Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging. Chemical communications (Cambridge, England). 47(26):7500-2.
Abstract
A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping