PUBLICATION

Synthesis of a new fluorescent small molecule probe and its use for in vivo lipid imaging

Authors
Lee, J.H., So, J.H., Jeon, J.H., Choi, E.B., Lee, Y.R., Chang, Y.T., Kim, C.H., Bae, M.A., and Ahn, J.H.
ID
ZDB-PUB-110523-13
Date
2011
Source
Chemical communications (Cambridge, England)   47(26): 7500-2 (Journal)
Registered Authors
Kim, Cheol-Hee, So, Ju-Hoon
Keywords
none
MeSH Terms
  • 3T3-L1 Cells
  • Adipose Tissue/metabolism
  • Animals
  • Fluorescent Dyes/chemical synthesis*
  • Fluorescent Dyes/chemistry*
  • Lipid Metabolism*
  • Mice
  • Molecular Imaging/methods*
  • Zebrafish
PubMed
21552617 Full text @ Chem. Commun. (Camb.)
Abstract
A new small molecule probe for in vivo lipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes