PUBLICATION
Toward a Better Understanding of Human Eye Disease Insights From the Zebrafish, Danio rerio
- Authors
- Bibliowicz, J., Tittle, R.K., and Gross, J.M.
- ID
- ZDB-PUB-110317-34
- Date
- 2011
- Source
- Progress in molecular biology and translational science 100: 287-300 (Review)
- Registered Authors
- Gross, Jeffrey, Tittle, Rachel
- Keywords
- Zebrafish, Eye, Ocular, Disease, Retina, Lens, RPE, Cornea, Glaucoma, Vasculature
- MeSH Terms
-
- Animals
- Anterior Eye Segment/pathology
- Disease Models, Animal*
- Eye Diseases/pathology*
- Humans
- Posterior Eye Segment/pathology
- Zebrafish/physiology*
- PubMed
- 21377629 Full text @ Prog. Mol. Biol. Transl. Sci.
Citation
Bibliowicz, J., Tittle, R.K., and Gross, J.M. (2011) Toward a Better Understanding of Human Eye Disease Insights From the Zebrafish, Danio rerio. Progress in molecular biology and translational science. 100:287-300.
Abstract
Visual impairment and blindness is widespread across the human population, and the development of therapies for ocular pathologies is of high priority. The zebrafish represents a valuable model organism for studying human ocular disease; it is utilized in eye research to understand underlying developmental processes, to identify potential causative genes for human disorders, and to develop therapies. Zebrafish eyes are similar in morphology, physiology, gene expression, and function to human eyes. Furthermore, zebrafish are highly amenable to laboratory research. This review outlines the use of zebrafish as a model for human ocular diseases such as colobomas, glaucoma, cataracts, photoreceptor degeneration, as well as dystrophies of the cornea and retinal pigmented epithelium.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping