PUBLICATION
Improving anticancer activity and reducing systemic toxicity of doxorubicin by self-assembled polymeric micelles
- Authors
- Gou, M., Shi, H., Guo, G., Men, K., Zhang, J., Zheng, L., Li, Z., Luo, F., Qian, Z., Zhao, X., and Wei, Y.
- ID
- ZDB-PUB-110131-32
- Date
- 2011
- Source
- Nanotechnology 22(9): 095102 (Journal)
- Registered Authors
- Zhao, Xia
- Keywords
- none
- MeSH Terms
-
- Animals
- Antibiotics, Antineoplastic/adverse effects
- Antibiotics, Antineoplastic/chemistry
- Antibiotics, Antineoplastic/therapeutic use
- Cell Line, Tumor
- Colonic Neoplasms/drug therapy*
- Colonic Neoplasms/pathology*
- Doxorubicin/adverse effects
- Doxorubicin/chemistry*
- Doxorubicin/therapeutic use*
- Drug Carriers/chemistry*
- Female
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Micelles
- Polyesters/chemistry*
- Polyethylene Glycols/chemistry*
- Treatment Outcome
- PubMed
- 21270494 Full text @ Nanotechnology
Citation
Gou, M., Shi, H., Guo, G., Men, K., Zhang, J., Zheng, L., Li, Z., Luo, F., Qian, Z., Zhao, X., and Wei, Y. (2011) Improving anticancer activity and reducing systemic toxicity of doxorubicin by self-assembled polymeric micelles. Nanotechnology. 22(9):095102.
Abstract
In an attempt to improve anticancer activity and reduce systemic toxicity of doxorubicin (Dox), we encapsulated Dox in monomethoxy poly(ethylene glycol)-poly(ยต-caprolactone) (MPEG-PCL) micelles by a novel self-assembly procedure without using surfactants, organic solvents or vigorous stirring. These Dox encapsulated MPEG-PCL (Dox/MPEG-PCL) micelles with drug loading of 4.2% were monodisperse and < 20 nm in diameter. The Dox can be released from the Dox/MPEG-PCL micelles; the Dox-release at pH 5.5 was faster than that at pH 7.0. Encapsulation of Dox in MPEG-PCL micelles enhanced the cellular uptake and cytotoxicity of Dox on the C-26 colon carcinoma cell in vitro, and slowed the extravasation of Dox in the transgenic zebrafish model. Compared to free Dox, Dox/MPEG-PCL micelles were more effective in inhibiting tumor growth in the subcutaneous C-26 colon carcinoma and Lewis lung carcinoma models, and prolonging survival of mice bearing these tumors. Dox/MPEG-PCL micelles also induced lower systemic toxicity than free Dox. In conclusion, incorporation of Dox in MPEG-PCL micelles enhanced the anticancer activity and decreased the systemic toxicity of Dox; these Dox/MPEG-PCL micelles are an interesting formulation of Dox and may have potential clinical applications in cancer therapy.
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