PUBLICATION
Disruption of zebrafish (Danio rerio) reproduction upon chronic exposure to TiO(2) nanoparticles
- Authors
- Wang, J., Zhu, X., Zhang, X., Zhao, Z., Liu, H., George, R., Wilson-Rawls, J., Chang, Y., and Chen, Y.
- ID
- ZDB-PUB-110119-39
- Date
- 2011
- Source
- Chemosphere 83(4): 461-7 (Journal)
- Registered Authors
- Chen, Yongsheng
- Keywords
- Acute toxicity, Bioaccumulation, Chronic toxicity, Microarry, Reproduction, Zebrafish, TiO2, Nanoparticles
- MeSH Terms
-
- Animals
- Titanium/metabolism
- Titanium/toxicity*
- Reproduction/drug effects*
- Zebrafish/growth & development
- Zebrafish/metabolism
- Zebrafish/physiology*
- Female
- Gene Expression/drug effects
- Metal Nanoparticles/toxicity*
- Ovary/drug effects
- Ovary/metabolism
- Ovary/pathology
- Male
- Water Pollutants, Chemical/toxicity*
- PubMed
- 21239038 Full text @ Chemosphere
Citation
Wang, J., Zhu, X., Zhang, X., Zhao, Z., Liu, H., George, R., Wilson-Rawls, J., Chang, Y., and Chen, Y. (2011) Disruption of zebrafish (Danio rerio) reproduction upon chronic exposure to TiO(2) nanoparticles. Chemosphere. 83(4):461-7.
Abstract
As common engineered nanomaterials, TiO(2) nanoparticles (nTiO(2)) are usually perceived as non-toxic, and have already been widely used in many products and applications. Such a perception might have been shaped by some short-term studies that revealed no/low toxicity of nTiO(2) to cells and eco-relevant organisms. However, given the ultimate release of nTiO(2) into the aquatic environment, which can act as a sink for engineered nanoparticles, their long-term impact on the environment and human health is still a concern and deserves more research efforts. Here, for the first time, we demonstrate that chronic exposure of zebrafish to 0.1mgL(-1) nTiO(2), can significantly impair zebrafish reproduction. For instance, there was a 29.5% reduction in the cumulative number of zebrafish eggs after 13weeks of nTiO(2) exposure. Thus, we provided timely information on indicating a serious risk of reproductive impairment of environments contaminated with low levels of nTiO(2) on aquatic organisms, leading to alterations in population dynamics and aquatic ecosystem balance, and thus warrants a careful scrutiny on toxicity assessment of nTiO(2), especially their long-term impact.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping