PUBLICATION
Mutations in the SPARC-Related Modular Calcium-Binding Protein 1 Gene, SMOC1, Cause Waardenburg Anophthalmia Syndrome
- Authors
- Abouzeid, H., Boisset, G., Favez, T., Youssef, M., Marzouk, I., Shakankiry, N., Bayoumi, N., Descombes, P., Agosti, C., Munier, F.L., and Schorderet, D.F.
- ID
- ZDB-PUB-110110-6
- Date
- 2011
- Source
- American journal of human genetics 88(1): 92-98 (Journal)
- Registered Authors
- Boisset, Gaëlle, Schorderet, Daniel
- Keywords
- none
- MeSH Terms
-
- Adult
- Base Sequence
- Child
- Consanguinity
- Eye/growth & development
- Female
- Fingers/growth & development
- Genes, Recessive
- Humans
- Male
- Molecular Sequence Data
- Mutation*
- Osteonectin/genetics*
- Pedigree
- Waardenburg Syndrome/genetics
- PubMed
- 21194680 Full text @ Am. J. Hum. Genet.
Citation
Abouzeid, H., Boisset, G., Favez, T., Youssef, M., Marzouk, I., Shakankiry, N., Bayoumi, N., Descombes, P., Agosti, C., Munier, F.L., and Schorderet, D.F. (2011) Mutations in the SPARC-Related Modular Calcium-Binding Protein 1 Gene, SMOC1, Cause Waardenburg Anophthalmia Syndrome. American journal of human genetics. 88(1):92-98.
Abstract
Waardenburg anophthalmia syndrome, also known as microphthalmia with limb anomalies, ophthalmoacromelic syndrome, and anophthalmia-syndactyly, is a rare autosomal-recessive developmental disorder that has been mapped to 10p11.23. Here we show that this disease is heterogeneous by reporting on a consanguineous family, not linked to the 10p11.23 locus, whose two affected children have a homozygous mutation in SMOC1. Knockdown experiments of the zebrafish smoc1 revealed that smoc1 is important in eye development and that it is expressed in many organs, including brain and somites.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping