PUBLICATION
Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models
- Authors
- Stewart, A., Wu, N., Cachat, J., Hart, P., Gaikwad, S., Wong, K., Utterback, E., Gilder, T., Kyzar, E., Newman, A., Carlos, D., Chang, K., Hook, M., Rhymes, C., Caffery, M., Greenberg, M., Zadina, J., and Kalueff, A.V.
- ID
- ZDB-PUB-101209-6
- Date
- 2011
- Source
- Progress in neuro-psychopharmacology & biological psychiatry 35(6): 1421-1431 (Review)
- Registered Authors
- Cachat, Jonathan, Kalueff, Allan V.
- Keywords
- Anxiety, Anxiolytic drugs, Anxiogenic drugs, Novelty-based paradigms, Novel tank test, Stress, Zebrafish
- MeSH Terms
-
- Animals
- Anti-Anxiety Agents/pharmacology*
- Anti-Anxiety Agents/therapeutic use*
- Anxiety/chemically induced
- Anxiety/drug therapy*
- Disease Models, Animal*
- Exploratory Behavior/drug effects
- Humans
- Phenotype
- Synaptic Transmission/drug effects*
- Zebrafish
- PubMed
- 21122812 Full text @ Prog. Neuropsychopharmacol. Biol. Psychiatry
Citation
Stewart, A., Wu, N., Cachat, J., Hart, P., Gaikwad, S., Wong, K., Utterback, E., Gilder, T., Kyzar, E., Newman, A., Carlos, D., Chang, K., Hook, M., Rhymes, C., Caffery, M., Greenberg, M., Zadina, J., and Kalueff, A.V. (2011) Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models. Progress in neuro-psychopharmacology & biological psychiatry. 35(6):1421-1431.
Abstract
Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping