PUBLICATION
The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse
- Authors
- Waller-Evans, H., Prömel, S., Langenhan, T., Dixon, J., Zahn, D., Colledge, W.H., Doran, J., Carlton, M.B., Davies, B., Aparicio, S.A., Grosse, J., and Russ, A.P.
- ID
- ZDB-PUB-101209-11
- Date
- 2010
- Source
- PLoS One 5(11): e14047 (Journal)
- Registered Authors
- Aparicio, Sam
- Keywords
- Embryos, Zebrafish, Genetic loci, Mammals, Mammalian genomics, Placenta, Reporter genes, Vertebrates
- MeSH Terms
-
- Animals
- Cardiovascular Abnormalities/embryology
- Cardiovascular Abnormalities/genetics
- Cardiovascular Abnormalities/metabolism
- Embryo, Mammalian/embryology
- Embryo, Mammalian/metabolism*
- Embryonic Development/genetics*
- Female
- Gene Expression Regulation, Developmental*
- Genotype
- Humans
- Immunohistochemistry
- Male
- Mice
- Mice, 129 Strain
- Mice, Inbred C57BL
- Mice, Knockout
- Myocardium/metabolism
- Myocardium/pathology
- Placenta/metabolism
- Pregnancy
- Receptors, G-Protein-Coupled/genetics*
- Receptors, G-Protein-Coupled/metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Time Factors
- PubMed
- 21124978 Full text @ PLoS One
Citation
Waller-Evans, H., Prömel, S., Langenhan, T., Dixon, J., Zahn, D., Colledge, W.H., Doran, J., Carlton, M.B., Davies, B., Aparicio, S.A., Grosse, J., and Russ, A.P. (2010) The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse. PLoS One. 5(11):e14047.
Abstract
Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates, but the function of most of these receptors is still not understood. The orphan Adhesion-GPCR GPR126 has recently been shown to play an essential role in the myelination of peripheral nerves in zebrafish. In parallel, whole-genome association studies have implicated variation at the GPR126 locus as a determinant of body height in the human population. The physiological function of GPR126 in mammals is still unknown. We describe a targeted mutation of GPR126 in the mouse, and show that GPR126 is required for embryonic viability and cardiovascular development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping