PUBLICATION
Acetylcholinesterase activity and antioxidant capacity of zebrafish brain is altered by heavy metal exposure
- Authors
- Richetti, S.K., Rosemberg, D.B., Ventura-Lima, J., Monserrat, J.M., Bogo, M.R., and Bonan, C.D.
- ID
- ZDB-PUB-101122-4
- Date
- 2011
- Source
- Neurotoxicology 32(1): 116-122 (Journal)
- Registered Authors
- Bonan, Carla Denise
- Keywords
- Heavy metal, Pollution, Acetylcholinesterase, Zebrafish, Oxidative stress
- MeSH Terms
-
- Acetylcholinesterase/metabolism*
- Animals
- Antioxidants/metabolism*
- Brain/drug effects*
- Brain/enzymology*
- Brain/metabolism
- Cholinesterase Inhibitors/administration & dosage
- Cholinesterase Inhibitors/toxicity
- Environmental Exposure/adverse effects*
- Enzyme Activation/drug effects
- Enzyme Activation/physiology
- Female
- Male
- Metals, Heavy/administration & dosage
- Metals, Heavy/toxicity*
- Zebrafish
- PubMed
- 21074552 Full text @ Neurotoxicology
- CTD
- 21074552
Citation
Richetti, S.K., Rosemberg, D.B., Ventura-Lima, J., Monserrat, J.M., Bogo, M.R., and Bonan, C.D. (2011) Acetylcholinesterase activity and antioxidant capacity of zebrafish brain is altered by heavy metal exposure. Neurotoxicology. 32(1):116-122.
Abstract
Pollution is a world problem with immeasurable consequences. Heavy metal compounds are frequently found as components of anthropogenic pollution. Here we evaluated the effects of the treatment with cadmium acetate, lead acetate, mercury chloride, and zinc chloride in acetylcholinesterase activity and gene expression pattern, as well as the effects of these treatments in antioxidant competence in the brain of an aquatic and well-established organism for toxicological analysis, zebrafish (Danio rerio, Cyprinidae). Mercury chloride and lead acetate promoted a significant decrease in acetylcholinesterase activity whereas they did not alter the gene expression pattern. In addition, the antioxidant competence was decreased after exposure to mercury chloride. The data presented here allowed us to hypothesize a signal transmission impairment, through alterations in cholinergic transmission, and also in the antioxidant competence of zebrafish brain tissue as some of the several effects elicited by these pollutants.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping