PUBLICATION
Xenopus er71 is involved in vascular development
- Authors
- Neuhaus, H., Müller, F., and Hollemann, T.
- ID
- ZDB-PUB-101115-19
- Date
- 2010
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 239(12): 3436-3445 (Journal)
- Registered Authors
- Keywords
- ets, vasculogenesis, hematopoiesis, msr, er71, early embryogenesis, vertebrate, Xenopus
- MeSH Terms
-
- Animals
- Blood Vessels/embryology*
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental/genetics
- Gene Expression Regulation, Developmental/physiology
- Hemangioblasts/cytology
- Hemangioblasts/metabolism
- Hematopoiesis/genetics
- Hematopoiesis/physiology*
- In Situ Hybridization
- Reverse Transcriptase Polymerase Chain Reaction
- Xenopus/embryology*
- Xenopus Proteins/genetics
- Xenopus Proteins/metabolism*
- PubMed
- 21069823 Full text @ Dev. Dyn.
Citation
Neuhaus, H., Müller, F., and Hollemann, T. (2010) Xenopus er71 is involved in vascular development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(12):3436-3445.
Abstract
Vasculogenesis and hematopoiesis are closely linked in developing vertebrates. Recently, the existence of a common progenitor of these two tissues, the hemangioblast, has been demonstrated in different organisms. In Xenopus early vascular and hematopoietic cells differentiate in a region called the anterior ventral blood island (aVBI). Differentiating cells from this region migrate out to form embryonic blood and part of the vascular structures of the early frog embryo. A number of members of the ETS family of transcription factors are expressed in endothelial cells and some of them play important roles at various stages of vascular development. The loss of ER71 function in mice led to a complete loss of blood and vascular structures. Similarly, knock down of the zebrafish homolog of er71, etsrp, greatly affected development of vascular structures and myeloid cells. We have identified the Xenopus ortholog of er71 and could show that er71 function in Xenopus is required for vasculogenesis, but not for the development of hematopoietic cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping