PUBLICATION
Filtering of visual information in the tectum by an identified neural circuit
- Authors
- Del Bene, F., Wyart, C., Robles, E., Tran, A., Looger, L., Scott, E.K., Isacoff, E.Y., and Baier, H.
- ID
- ZDB-PUB-101101-16
- Date
- 2010
- Source
- Science (New York, N.Y.) 330(6004): 669-673 (Journal)
- Registered Authors
- Baier, Herwig, Del Bene, Filippo, Robles, Estuardo, Scott, Ethan, Wyart, Claire
- Keywords
- none
- MeSH Terms
-
- Neural Inhibition
- Dendrites/physiology
- Zebrafish
- Bicuculline/pharmacology
- Neuropil/physiology
- gamma-Aminobutyric Acid/metabolism
- Synaptic Transmission
- GABA Antagonists/pharmacology
- Axons/physiology
- Retina/physiology*
- Optic Lobe, Nonmammalian/cytology
- Optic Lobe, Nonmammalian/physiology*
- Visual Perception*
- Photic Stimulation
- Visual Pathways/physiology*
- Retinal Neurons/physiology
- Interneurons/physiology*
- Animals
- Animals, Genetically Modified
- Neurons/physiology*
- PubMed
- 21030657 Full text @ Science
Citation
Del Bene, F., Wyart, C., Robles, E., Tran, A., Looger, L., Scott, E.K., Isacoff, E.Y., and Baier, H. (2010) Filtering of visual information in the tectum by an identified neural circuit. Science (New York, N.Y.). 330(6004):669-673.
Abstract
The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encoded calcium indicator revealed that the deep layers, as well as the dendrites of single tectal neurons, are preferentially activated by small visual stimuli. This spatial filtering relies on GABAergic interneurons (using the neurotransmitter &gamma-aminobutyric acid) that are located in the superficial input layer and respond only to large visual stimuli. Photo-ablation of these cells with KillerRed, or silencing of their synaptic transmission, eliminates the size tuning of deeper layers and impairs the capture of prey.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping