PUBLICATION
Ghrelin: a multifunctional hormone in non-mammalian vertebrates
- Authors
- Kaiya, H., Miyazato, M., Kangawa, K., Peter, R.E., and Unniappan, S.
- ID
- ZDB-PUB-101027-52
- Date
- 2008
- Source
- Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 149(2): 109-128 (Review)
- Registered Authors
- Unniappan, Suraj
- Keywords
- Amphibians, Birds, Brain, Fish, Food intake, Ghrelin, Gut, Hormones, Peptides, Reptiles
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Brain/metabolism
- Eating/physiology
- Gastric Mucosa/metabolism*
- Ghrelin/chemistry
- Ghrelin/metabolism*
- Growth Hormone-Releasing Hormone/chemistry
- Growth Hormone-Releasing Hormone/metabolism
- Humans
- Molecular Sequence Data
- Protein Conformation
- Receptors, Ghrelin/metabolism
- Stomach/metabolism*
- Vertebrates
- PubMed
- 18222718 Full text @ Comp. Biochem. Physiol. A Mol. Integr. Physiol.
Citation
Kaiya, H., Miyazato, M., Kangawa, K., Peter, R.E., and Unniappan, S. (2008) Ghrelin: a multifunctional hormone in non-mammalian vertebrates. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 149(2):109-128.
Abstract
In mammals, ghrelin is a non-amidated peptide hormone, existing in both acylated and non-acylated forms, produced mainly from the X/A or ghrelin cells present in the mucosal layer of the stomach. Ghrelin is a natural ligand of the growth hormone (GH) secretagogue-receptor (GHS-R), and functions primarily as a GH-releasing hormone and an orexigen, as well as having several other biological actions. Among non-mammalian vertebrates, amino acid sequence of ghrelin has been reported in two species of cartilaginous fish, seven species of teleosts, two species of amphibians, one species of reptile and six species of birds. The structure and functions of ghrelin are highly conserved among vertebrates. This review presents a concise overview of ghrelin biology in non-mammalian vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping