PUBLICATION
The effects of hyperglycemia on adrenal cortex function and steroidogenesis in the zebrafish
- Authors
- Powers, J.W., Mazilu, J.K., Lin, S., and McCabe, E.R.
- ID
- ZDB-PUB-101027-23
- Date
- 2010
- Source
- Molecular genetics and metabolism 101(4): 421-422 (Journal)
- Registered Authors
- Lin, Shuo
- Keywords
- Diabetes mellitus, Hyperglycemia, Cortisol, Zebrafish
- MeSH Terms
-
- Adrenal Cortex/physiopathology*
- Animals
- Disease Models, Animal
- Glucose/metabolism
- Hydrocortisone/metabolism
- Hyperglycemia/metabolism*
- Hyperglycemia/physiopathology*
- Pituitary-Adrenal System/physiopathology
- Steroids/biosynthesis*
- Zebrafish
- PubMed
- 20961780 Full text @ Mol. Genet. Metab.
Citation
Powers, J.W., Mazilu, J.K., Lin, S., and McCabe, E.R. (2010) The effects of hyperglycemia on adrenal cortex function and steroidogenesis in the zebrafish. Molecular genetics and metabolism. 101(4):421-422.
Abstract
Since the 1950s, scientists have attempted to characterize the relationship between diabetes mellitus (DM) and the hypothalamic-pituitary-adrenal (HPA) axis. Similar complications are seen in patients with diabetes and Cushing's syndrome, leading some to suggest that an underlying abnormality in the HPA axis may be responsible among those with DM. By inducing hyperglycemia in a zebrafish animal model, we show a direct correlation between glucose and cortisol levels.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping