|ZFIN ID: ZDB-PUB-101011-15|
The zebrafish embryo as a model for assessing off-target drug effects
Strähle, U., and Grabher, C.
|Source:||Disease models & mechanisms 3(11-12): 689-692 (Review)|
|Registered Authors:||Grabher, Clemens, Strähle, Uwe|
|PubMed:||20876356 Full text @ Dis. Model. Mech.|
Strähle, U., and Grabher, C. (2010) The zebrafish embryo as a model for assessing off-target drug effects. Disease models & mechanisms. 3(11-12):689-692.
ABSTRACTAlthough first used experimentally for the genetic analysis of vertebrate development and neurobiology, the zebrafish has been adapted as a model for many human diseases. In recent years, the zebrafish embryo has increasingly attracted the attention of chemists and pharmacologists for its utility in identifying chemicals with pharmacological activity in a whole-animal context. Its experimental virtues make it an ideal system with which to identify new bioactive molecules, and to assess their toxicity and teratogenicity at medium-to-high throughput. More recently, the zebrafish embryo has been applied to identify off-target effects of drug candidates. Here, we discuss the value of the zebrafish embryo for detecting off-target effects, and propose that this model could be useful for improving the efficiency of the drug-development pipeline.
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