PUBLICATION
The zebrafish embryo as a model for assessing off-target drug effects
- Authors
- Strähle, U., and Grabher, C.
- ID
- ZDB-PUB-101011-15
- Date
- 2010
- Source
- Disease models & mechanisms 3(11-12): 689-692 (Review)
- Registered Authors
- Grabher, Clemens, Strähle, Uwe
- Keywords
- none
- MeSH Terms
-
- Animals
- Benzothiazoles/pharmacology
- Cholinesterase Inhibitors/pharmacology
- DNA-Binding Proteins/antagonists & inhibitors
- DNA-Binding Proteins/metabolism
- Drug-Related Side Effects and Adverse Reactions*
- Embryo, Nonmammalian/drug effects*
- Humans
- Models, Animal*
- Nuclear Proteins/antagonists & inhibitors
- Nuclear Proteins/metabolism
- Pyrazoles/pharmacology
- Pyrimidines/pharmacology
- Toluene/analogs & derivatives
- Toluene/pharmacology
- Tumor Suppressor Protein p53/antagonists & inhibitors
- Tumor Suppressor Protein p53/metabolism
- Tumor Suppressor Proteins/antagonists & inhibitors
- Tumor Suppressor Proteins/metabolism
- Zebrafish/embryology*
- PubMed
- 20876356 Full text @ Dis. Model. Mech.
Citation
Strähle, U., and Grabher, C. (2010) The zebrafish embryo as a model for assessing off-target drug effects. Disease models & mechanisms. 3(11-12):689-692.
Abstract
Although first used experimentally for the genetic analysis of vertebrate development and neurobiology, the zebrafish has been adapted as a model for many human diseases. In recent years, the zebrafish embryo has increasingly attracted the attention of chemists and pharmacologists for its utility in identifying chemicals with pharmacological activity in a whole-animal context. Its experimental virtues make it an ideal system with which to identify new bioactive molecules, and to assess their toxicity and teratogenicity at medium-to-high throughput. More recently, the zebrafish embryo has been applied to identify off-target effects of drug candidates. Here, we discuss the value of the zebrafish embryo for detecting off-target effects, and propose that this model could be useful for improving the efficiency of the drug-development pipeline.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping