PUBLICATION
Effect of triazophos, fipronil and their mixture on miRNA expression in adult zebrafish
- Authors
- Wang, X., Zhou, S., Ding, X., Zhu, G., and Guo, J.
- ID
- ZDB-PUB-100910-36
- Date
- 2010
- Source
- Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 45(7): 648-657 (Journal)
- Registered Authors
- Keywords
- Zebrafish, fipronil, triazophos, pesticide, miRNA, microarray, toxicity
- MeSH Terms
-
- Animals
- Environmental Monitoring
- Gene Expression Regulation/drug effects*
- MicroRNAs/genetics*
- MicroRNAs/metabolism
- Organothiophosphates/pharmacology*
- Pesticides/pharmacology*
- Pyrazoles/pharmacology*
- Triazoles/pharmacology*
- Zebrafish/genetics*
- Zebrafish/metabolism
- PubMed
- 20818518 Full text @ J. Environ. Sci. Health B
Citation
Wang, X., Zhou, S., Ding, X., Zhu, G., and Guo, J. (2010) Effect of triazophos, fipronil and their mixture on miRNA expression in adult zebrafish. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 45(7):648-657.
Abstract
MicroRNA (miRNA) plays a crucial role in gene expression regulation. However, no data are available on change of miRNA expression of zebrafish (Danio rerio) after treatment with pesticides. We evaluated the effect of fipronil (5-amino-1-[2, 6-dichloro-4-(trifluoromethyl) phenyl]-4-[(trifluoromethyl) sulfinyl]-1H-pyrazole-3-carbonitrile) and triazophos (3-(O, O-diethyl)-1-phenyl thiophosphoryl-1, 2, 4-triazol) and their mixture on miRNA expression in zebrafish.MiRNA expression profiles in zebrafish were altered after treatment with these chemicals. An association between these chemicals and the expression of 21 miRNAs was found 96 h after treatment. Among them, 14 miRNAs were differentially expressed due to the treatments with fipronil, triazophos and their mixture; 5 miRNAs showed altered expression level after treatment with formulations of these chemicals; miR-29b and miR-738 were differentially expressed after treatment with adjuvants. MiRNAs might present a novel toxicological response that could be used as a toxicological biomarker and have a different direction for future investigations of their association with miRNAs involved in chemical related diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping