PUBLICATION
Hematopoietic development in the zebrafish
- Authors
- Paik, E.J., and Zon, L.I.
- ID
- ZDB-PUB-100820-15
- Date
- 2010
- Source
- The International journal of developmental biology 54(6-7): 1127-1137 (Review)
- Registered Authors
- Zon, Leonard I.
- Keywords
- hematopoietic stem cell, HSC, hemangioblast, primitive hematopoiesis, definitive hematopoiesis
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian/blood supply
- Embryo, Nonmammalian/embryology
- Embryo, Nonmammalian/metabolism
- GATA1 Transcription Factor/genetics
- Gene Expression Regulation, Developmental
- Hematopoiesis/genetics*
- Models, Genetic
- Mutation*
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish Proteins/genetics*
- PubMed
- 20711990 Full text @ Int. J. Dev. Biol.
Citation
Paik, E.J., and Zon, L.I. (2010) Hematopoietic development in the zebrafish. The International journal of developmental biology. 54(6-7):1127-1137.
Abstract
The model organism Danio rerio, also known as the zebrafish, is an excellent system for studying the developmental process of hematopoiesis. It is an ideal model for in vivo imaging, and it is useful for large-scale genetic screens. These have led to the discovery of previously unknown players in hematopoiesis, as well as helped our understanding of hematopoietic development. In this review, we will summarize hematopoiesis in the zebrafish and discuss how genetic approaches using the zebrafish system have helped to build our current knowledge in the field of hematopoiesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping