PUBLICATION
Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio)
- Authors
- Seibt, K.J., Oliveira, R.D., Zimmermann, F.F., Capiotti, K.M., Bogo, M.R., Ghisleni, G., and Bonan, C.D.
- ID
- ZDB-PUB-100719-9
- Date
- 2010
- Source
- Behavioural brain research 214(2): 417-422 (Journal)
- Registered Authors
- Bonan, Carla Denise
- Keywords
- MK-801, Antipsychotics, Zebrafish, Locomotor activity, Anxiety, Schizophrenia
- MeSH Terms
-
- Animals
- Antipsychotic Agents/pharmacology*
- Dizocilpine Maleate/antagonists & inhibitors*
- Dizocilpine Maleate/pharmacology
- Excitatory Amino Acid Antagonists/pharmacology
- Female
- Hallucinogens/antagonists & inhibitors*
- Hallucinogens/pharmacology
- Hyperkinesis/chemically induced
- Hyperkinesis/prevention & control*
- Male
- Motor Activity/drug effects
- Zebrafish
- PubMed
- 20600350 Full text @ Behav. Brain Res.
Citation
Seibt, K.J., Oliveira, R.D., Zimmermann, F.F., Capiotti, K.M., Bogo, M.R., Ghisleni, G., and Bonan, C.D. (2010) Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio). Behavioural brain research. 214(2):417-422.
Abstract
Glutamate N-methyl-d-aspartate (NMDA) receptor antagonists, such as dizocilpine (MK-801), elicit schizophrenia-like symptoms in humans and a behavioral syndrome in rodents, characterized by hyperlocomotion and stereotyped actions, which is antagonized by antipsychotic drugs. Animal models of schizophrenia have been established and used for the development of new antipsychotic drugs. In this work we characterized the behavioral effects of MK-801 and investigated the effect of typical and atypical antipsychotic treatments on locomotor activity as well on the hyperlocomotion induced by MK-801 in zebrafish. MK-801 (20muM) increased the locomotor behavior as measured by the number of line crossings, distance traveled, and the mean speed in the tank test after 15, 30, and 60min of exposure. All tested antipsychotics counteracted MK-801-induced hyperactivity on all parameters analyzed and at doses that, given alone, had no effect on spontaneous locomotor activity. The results suggest a similar profile between typical and atypical antipsychotics in the reversal of locomotor disorders induced by MK-801. Moreover, an anxiolytic effect was verified at 30 and 60min of MK-801 exposure, which was not reversed by antipsychotics tested in this work. In addition, olanzapine, which alone caused an anxiolytic response, when given with MK-801 potentiated the latter's effect on anxiety. In this work we demonstrated the value of the zebrafish, a simple to use animal model, in developing some behavioral features observed in schizophrenia, which may indicate a new approach for drug screening.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping