Community Action Needed: Please respond to the NIH RFI
ZFIN ID: ZDB-PUB-100702-6
In the swim of things: recent insights to neurogenetic disorders from zebrafish
Kabashi, E., Champagne, N., Brustein, E., and Drapeau, P.
Date: 2010
Source: Trends in genetics : TIG   26(8): 373-381 (Review)
Registered Authors: Brustein, Edna, Drapeau, Pierre
Keywords: none
MeSH Terms:
  • Animals
  • Central Nervous System Diseases/genetics
  • Central Nervous System Diseases/physiopathology
  • Disease Models, Animal
  • Humans
  • Mutation
  • Neurodegenerative Diseases/genetics*
  • Neurodegenerative Diseases/physiopathology
  • Swimming*
  • Zebrafish/abnormalities*
  • Zebrafish/genetics*
PubMed: 20580116 Full text @ Trends Genet.
ABSTRACT
The advantage of zebrafish as a model to study human pathologies lies in the ease of manipulating gene expression in vivo. Here we focus on recent progress in our understanding of motor neuron diseases and neurodevelopmental disorders and discuss how novel technologies will permit further disease models to be developed. Together these advances set the stage for this simple functional model, with particular advantages for transgenesis, multigenic analyses and chemical biology, to become uniquely suited for advancing the functional genomics of neurological and possibly psychiatric diseases - from understanding the genetics and cell biology of degenerative and developmental disorders to the discovery of therapeutics.
ADDITIONAL INFORMATION No data available