PUBLICATION
Expression of strawberry notch family genes during zebrafish embryogenesis
- Authors
- Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y.
- ID
- ZDB-PUB-100601-9
- Date
- 2010
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 239(6): 1789-1796 (Journal)
- Registered Authors
- Hibi, Masahiko
- Keywords
- zebrafish, brain development, strawberry notch, gene expression
- MeSH Terms
-
- Animals
- Central Nervous System
- Embryo, Nonmammalian
- Embryonic Development/genetics*
- Gene Expression
- Nervous System/embryology
- Repressor Proteins/genetics*
- Zebrafish/genetics*
- Zebrafish/metabolism*
- PubMed
- 20503374 Full text @ Dev. Dyn.
Citation
Takano, A., Zochi, R., Hibi, M., Terashima, T., and Katsuyama, Y. (2010) Expression of strawberry notch family genes during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(6):1789-1796.
Abstract
Our previous study suggested a possible role for Sbno1, a mouse homologue of strawberry notch gene during brain development. In this report, we cloned the zebrafish homologues of sbno, and examined their expression pattern during embryogenesis by whole-mount in situ hybridization. Zebrafish have three sbno genes: one Sbno1 homologue and two Sbno2 homologues, sbno2a and sbno2b. We observed that the expression of sbno1 and sbno2a was initially ubiquitous and gradually became predominant in the central nervous system as development progressed. The expression of sbno2b was observed in non-neural tissues in contrast to the other two genes. sbno1 and sbno2a exhibited higher expression in distinct regions within the nervous system of pharyngula-stage embryos, suggesting possible differing roles for sbno1 and sbno2a during later stages of embryogenesis. Together, the observed gene expression patterns suggest an important role of sbno-family genes during development of the vertebrate central nervous system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping