PUBLICATION
Chemical constituents of Excoecaria acerifolia and their bioactivities
- Authors
- Zhao, Y.L., He, Q.X., Li, Y., Wang, S.F., Liu, K.C., Yang, Y.P., and Li, X.L.
- ID
- ZDB-PUB-100504-11
- Date
- 2010
- Source
- Molecules 15(4): 2178-2186 (Journal)
- Registered Authors
- Li, Yang
- Keywords
- kaurane diterpenoid, Excoecaria acerifolia, NMR, antiangiogenic, antiproliferative
- MeSH Terms
-
- Angiogenesis Inhibitors/chemistry*
- Angiogenesis Inhibitors/isolation & purification
- Angiogenesis Inhibitors/pharmacology
- Animals
- Antineoplastic Agents/chemistry*
- Antineoplastic Agents/isolation & purification
- Antineoplastic Agents/pharmacology
- Apoptosis
- Cell Line, Tumor
- Euphorbiaceae/chemistry*
- Humans
- Zebrafish
- PubMed
- 20428036 Full text @ Molecules
Citation
Zhao, Y.L., He, Q.X., Li, Y., Wang, S.F., Liu, K.C., Yang, Y.P., and Li, X.L. (2010) Chemical constituents of Excoecaria acerifolia and their bioactivities. Molecules. 15(4):2178-2186.
Abstract
A new kaurane diterpenoid, 3alpha,18-dihydroxy-3beta,20-epoxykaur-15-ene (1), was isolated from the aerial parts of Excoecaria acerifolia (Euphorbiaceae) together with 16 known compounds. Their structures were identified by extensive spectral analysis, especially 2D NMR techniques. Antiangiogenic effects of compounds 1-6 and 9-17 were evaluated using a zebrafish model, with compound 9 being active in this bioassay. At the same time, compounds 4, 6, 10, 11 showed activity in inhibiting the growth of A549 lung cancer cells, and the compound 10 also showed apoptosis-inducing effects on A549 lung cancer cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping