PUBLICATION
Emergence of traveling waves in the zebrafish segmentation clock
- Authors
- Ishimatsu, K., Takamatsu, A., and Takeda, H.
- ID
- ZDB-PUB-100420-34
- Date
- 2010
- Source
- Development (Cambridge, England) 137(10): 1595-1599 (Journal)
- Registered Authors
- Takeda, Hiroyuki
- Keywords
- Fgf, her1, Oscillation, Segmentation clock, Traveling waves, Zebrafish
- MeSH Terms
-
- Models, Biological
- Zebrafish Proteins/genetics*
- Zebrafish Proteins/metabolism
- Zebrafish Proteins/physiology
- Somites/embryology
- Somites/metabolism
- Body Patterning/genetics*
- Body Patterning/physiology
- Embryo, Nonmammalian
- Animals, Genetically Modified
- Cleavage Stage, Ovum/metabolism
- Cleavage Stage, Ovum/physiology
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish/physiology
- Fibroblast Growth Factors/genetics
- Fibroblast Growth Factors/metabolism
- Fibroblast Growth Factors/physiology
- Gene Expression Regulation, Developmental*
- Animals
- Biological Clocks/genetics
- Biological Clocks/physiology*
- Signal Transduction
- Basic Helix-Loop-Helix Transcription Factors/genetics*
- Basic Helix-Loop-Helix Transcription Factors/metabolism
- PubMed
- 20392739 Full text @ Development
Citation
Ishimatsu, K., Takamatsu, A., and Takeda, H. (2010) Emergence of traveling waves in the zebrafish segmentation clock. Development (Cambridge, England). 137(10):1595-1599.
Abstract
The spatial and temporal periodicity of somite formation is controlled by the segmentation clock, in which numerous cells cyclically express hairy-related transcriptional repressors with a posterior-to-anterior phase delay, creating 'traveling waves' of her1 expression. In zebrafish, the first traveling wave buds off from the synchronous oscillation zone in the blastoderm margin. Here we show that the emergence of a traveling wave coincides with the anterior expansion of Fgf signaling and that transplanted Fgf8b-soaked beads induce ectopic traveling waves. We thus propose that as development proceeds, the activity of Fgf signaling gradually expands anteriorly, starting from the margin, so that cells initiate her1 oscillation with a posterior-to-anterior phase delay. Furthermore, we suggest that Fgf has an essential role in establishing the period gradient that is required for the her1 spatial oscillation pattern at the emergence of the traveling wave.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping