Exploring Alzheimer's Disease in Zebrafish
- Xia, W.
- Journal of Alzheimer's disease : JAD 20(4): 981-990 (Review)
- Registered Authors
- Xia, Weiming
- Alzheimer, amyloid, secretase, tau, transgenic, zebrafish
- MeSH Terms
- Alzheimer Disease/pathology*
- Amyloid Precursor Protein Secretases/antagonists & inhibitors
- Amyloid Precursor Protein Secretases/metabolism
- Amyloid beta-Peptides/genetics
- Amyloid beta-Protein Precursor/genetics
- Animals, Genetically Modified
- Apolipoproteins E/genetics
- Receptors, Notch/metabolism
- Zebrafish Proteins/genetics
- tau Proteins/genetics
- 20182049 Full text @ J. Alzheimers Dis.
Xia, W. (2010) Exploring Alzheimer's Disease in Zebrafish. Journal of Alzheimer's disease : JAD. 20(4):981-990.
The amyloid beta protein (Abeta)-containing neuritic plaques and hyperphosphorylated tau-containing neurofibrillary tangles are two invariable characteristics of Alzheimer's disease (AD). Three genes encoding amyloid-beta protein precursor (AbetaPP), presenilin (PS) 1 and 2 are linked to early onset familial AD, and the apolipoprotein E (ApoE) epsilon4 allele is a major risk factor for sporadic AD. The zebrafish AbetaPP, PS, and ApoE genes have been identified, and the essential components of the gamma-secretase complex that mediates cleavage of AbetaPP to generate Abeta have been examined in zebrafish. The transgenic zebrafish expressing mutant tau has been created, and the transparent animals exhibit the phenotype of neurodegeneration that could be readily characterized by capturing microscopic images. The application of zebrafish as a model system for AD research has expanded our knowledge of Abeta and tau, two components of AD pathological inclusions.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes