PUBLICATION

Swimming into the future of drug discovery: in vivo chemical screens in zebrafish

Authors
Bowman, T.V., and Zon, L.I.
ID
ZDB-PUB-100223-47
Date
2010
Source
ACS Chemical Biology   5(2): 159-161 (Review)
Registered Authors
Bowman, Teresa, Zon, Leonard I.
Keywords
none
MeSH Terms
  • Animals
  • Drug Discovery/methods*
  • Drug Evaluation, Preclinical/methods
  • Small Molecule Libraries*
  • Zebrafish/metabolism*
PubMed
20166761 Full text @ ACS Chem. Biol.
Abstract
In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.
Genes / Markers
Figures
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Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes