PUBLICATION
Pathological angiogenesis facilitates tumor cell dissemination and metastasis
- Authors
- Rouhi, P., Lee, S.L., Cao, Z., Hedlund, E.M., Jensen, L.D., and Cao, Y.
- ID
- ZDB-PUB-100223-38
- Date
- 2010
- Source
- Cell cycle (Georgetown, Tex.) 9(5): 913-917 (Journal)
- Registered Authors
- Lee, Samantha Lin Chiou
- Keywords
- none
- MeSH Terms
-
- Animals
- Hypoxia
- Models, Animal
- Neoplasm Invasiveness*
- Neoplasm Metastasis*
- Neovascularization, Pathologic*
- Vascular Endothelial Growth Factor A/metabolism
- Zebrafish
- PubMed
- 20160500 Full text @ Cell Cycle
Citation
Rouhi, P., Lee, S.L., Cao, Z., Hedlund, E.M., Jensen, L.D., and Cao, Y. (2010) Pathological angiogenesis facilitates tumor cell dissemination and metastasis. Cell cycle (Georgetown, Tex.). 9(5):913-917.
Abstract
Clinically detectable metastases represent an ultimate consequence of the metastatic cascade that consists of distinct processes including tumor cell invasion, dissemination, metastatic niche formation, and re-growth into a detectable metastatic mass. Although angiogenesis is known to promote tumor growth, its role in facilitating early events of the metastatic cascade remains poorly understood. We have recently developed a zebrafish tumor model that enables us to study involvement of pathological angiogenesis in tumor invasion, dissemination and metastasis. This non-invasive in vivo model allows detection of single malignant cell dissemination under both normoxia and hypoxia. Further, hypoxia-induced VEGF significantly facilitates tumor cell invasion and dissemination. These findings demonstrate that VEGF-induced pathological angiogenesis is essential for tumor dissemination and further corroborates potentially beneficial effects of clinically ongoing anti-VEGF drugs for the treatment of various malignancies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping