ZFIN ID: ZDB-PUB-100112-29
Differential expression of neuroligin genes in the nervous system of zebrafish
Davey, C., Tallafuss, A., and Washbourne, P.
Date: 2010
Source: Developmental dynamics : an official publication of the American Association of Anatomists   239(2): 703-714 (Journal)
Registered Authors: Davey, Chrystal, Tallafuss, Alexandra, Washbourne, Philip
Keywords: nlgn, NL, Nlg, cell adhesion, synapse, central nervous system
MeSH Terms:
  • Animals
  • Brain/metabolism
  • Embryonic Development*
  • Gene Expression Profiling
  • Humans
  • Mice
  • Multigene Family*
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/metabolism*
  • Nervous System/embryology
  • Nervous System/metabolism*
  • Neurons/metabolism
  • Spinal Cord/metabolism
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism*
PubMed: 20063411 Full text @ Dev. Dyn.
The establishment and maturation of appropriate synaptic connections is crucial in the development of neuronal circuits. Cellular adhesion is believed to play a central role in this process. Neuroligins are neuronal cell adhesion molecules that are hypothesized to act in the initial formation and maturation of synaptic connections. In order to establish the zebrafish as a model to investigate the in vivo role of Neuroligin proteins in nervous system development, we identified the zebrafish orthologs of neuroligin family members and characterized their expression. Zebrafish possess seven neuroligin genes. Synteny analysis and sequence comparisons show that NLGN2, NLGN3, and NLGN4X are duplicated in zebrafish, but NLGN1 has a single zebrafish ortholog. All seven zebrafish neuroligins are expressed in complex patterns in the developing nervous system and in the adult brain. The spatial and temporal expression patterns of these genes suggest that they occupy a role in nervous system development and maintenance.