PUBLICATION
Non-mammalian animal models to study infectious disease: worms or fly fishing?
- Authors
- O'Callaghan, D., and Vergunst, A.
- ID
- ZDB-PUB-100105-45
- Date
- 2010
- Source
- Current opinion in microbiology 13(1): 79-85 (Review)
- Registered Authors
- Vergunst, Annette
- Keywords
- none
- MeSH Terms
-
- Animals
- Bacteria/pathogenicity*
- Bacterial Infections/microbiology*
- Bacterial Infections/pathology*
- Caenorhabditis elegans/microbiology*
- Disease Models, Animal*
- Drosophila melanogaster/microbiology*
- Humans
- Zebrafish/microbiology*
- PubMed
- 20045373 Full text @ Curr. Opin. Microbiol.
Citation
O'Callaghan, D., and Vergunst, A. (2010) Non-mammalian animal models to study infectious disease: worms or fly fishing?. Current opinion in microbiology. 13(1):79-85.
Abstract
A major challenge in studying human infectious diseases is to understand in detail the molecular bases, including both pathogen and host-related factors, which contribute to disease development. Non-mammalian models have proven to be of great value for our understanding of disease and have shown conservation in fundamental virulence mechanisms for the infection of evolutionary divergent hosts. In this review we describe recent advances with three major non-mammalian models used for analysis of infectious disease in humans; the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster and the zebrafish Danio rerio.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping