PUBLICATION

Non-mammalian animal models to study infectious disease: worms or fly fishing?

Authors
O'Callaghan, D., and Vergunst, A.
ID
ZDB-PUB-100105-45
Date
2010
Source
Current opinion in microbiology   13(1): 79-85 (Review)
Registered Authors
Vergunst, Annette
Keywords
none
MeSH Terms
  • Animals
  • Bacteria/pathogenicity*
  • Bacterial Infections/microbiology*
  • Bacterial Infections/pathology*
  • Caenorhabditis elegans/microbiology*
  • Disease Models, Animal*
  • Drosophila melanogaster/microbiology*
  • Humans
  • Zebrafish/microbiology*
PubMed
20045373 Full text @ Curr. Opin. Microbiol.
Abstract
A major challenge in studying human infectious diseases is to understand in detail the molecular bases, including both pathogen and host-related factors, which contribute to disease development. Non-mammalian models have proven to be of great value for our understanding of disease and have shown conservation in fundamental virulence mechanisms for the infection of evolutionary divergent hosts. In this review we describe recent advances with three major non-mammalian models used for analysis of infectious disease in humans; the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster and the zebrafish Danio rerio.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping